I voted no because of the word "major".
I ordered my car in Apr 2012, and finally got it home at the end of June '12. It has 88K kms (~55,000 miles) on it and is my daily driver. It is a fairly early (#2955) first year car, and I've had a few issues along the way...
An annoying rattle/vibration noise coming from the right rear area at highway speeds, most noticeable on a windy day or when passing a truck. Drove me nuts until I figured it out...fixed that one with a few dollars worth of neoprene washers under the head of the plastic rivets (clips) that hold the rear wheel well liner in.
Rattly under panel below transmission...fixed with some rubber washers left over from the wheelwell liners.
Both taillights...one warranty, one after warranty.
The seal on the little front 1/4 window, twice...warranty repair (seal was tearing at the top edge). This seal is part of the window and can not be replaced separately.
Both door rubbers for folding up as the window closes...warranty.
Dash for coming unglued in the center above the vents...warranty.
Sticky right front brake caliper...after warranty.
Noisy blower (heater fan) motor...after warranty
Rattly, loose door mirrors...fixed it myself in a few minutes thanks to @
supramkivtt2jz
Crunchy 2nd gear engagement...Pentosin
Crickets...3 solutions. Either burn fuel with no ethanol, burn fuel with ethanol, and add a small amount (1-2 oz) of 2-stroke oil per tank, or don't drive the car above 50 degrees F ambient temps.
There's probably a couple of other things I've forgotten about...
I will admit some of the clutch/TOB posts have me a little concerned.
Would any (or all) of these things make me regret buying this car? Not for a second! I knew I was getting a first year car, and expected a few issues going in. The little list above is a small price to pay for 55,000 miles of joy.