I just drove a new route I put together which was a hybrid of a run from Berks and a run starting in the LV. This would be a good LV/Berks run.
It starts at the Target on Cedar Crest Blvd and ends at the CrackerBarrel in Fogelsville, PA, which makes the after-brunch drive home about 1hr for the Philadelphians, and about 1.25 hrs for the New Jersey folks.
Route:
http://goo.gl/maps/aw6JT
The roads all pretty much backroads and very empty the more west we get at around 10-11am. Kister Road by Schnecksville, Windsor Castle by Hamburg, Mountain Road by Locust Lake are all epic.
The connectors are all long-windy roads with a couple of twisties here and there, but mostly forest viewing or sight viewing, which is pretty nice.