We used to use this years ago before the local Sheets started carrying E85. Think of it as a more precise E85 vs pump E85 that can vary in content.
Generally tuners tune for E50 levels (with flex fuel) and anything above that is considered additional knock protection. So, if you are thinking of doing this to chase a few HP I don't think it will be fruitful. The next step is E98, which has its own issues.
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