[bucketfoot]

What you will experience is ride dynamics that are much stiffer, as the biggest difference in a runflat tire is a much stiffer sidewall. This is what lets you drive on a flat tire without immediately shredding the tire.

As for rough roads and potholes, you will absolutely experience a rougher ride and will probably be at a higher risk level of damaging your rims (although I really don't know how much of an increase).

Initially I kept the runflats on my last car, as my wife would drive it at times and I didn't want her possibly getting stuck in a car that did not have a spare (FYI, improving MPG by the weight reduction of eliminating the spare tire is the most common reason car makers use them). Once my wife decided she wasn't going to drive the car often I made the switch to regular tires. The difference in ride was quite apparent.

One of the first things many enthusiasts do when getting a sporty car with runflats is to get rid of them, as the driving dynamics are pretty much always much better with standard tires. On top of this there is a miniscule selection of runflats compared to normal tires making it much more difficult to get a tire that fits your particular driving style or needs.

If the safety aspects of a runflat outweigh the driving dynamics of a car, by all means go that route. Ultimately only you can decide what is right for you.