[Mr.ac]

Pretty much the same thought I had.
Yes it could be done, some have already done it. Your Google-fu is weak, but just takes a bit of work, but not hard.

However 10" subs would be too big. I would go with either 8" or 6" subs.
I wouldn't bother keeping the 4" full range speakers.

Then only issues I see is panel rattles. But there's always a fix for that.

Enclosure size is pretty simple, no need for fancy software, just good ol' math. The way I figured out the internal volume on my custom set ups was to fill it with water. Measure it, do the math, go from there. Simple, just add a garbage bag so you don't ruin the enclosure.